Reynie's PhD looked at the impact of HCV and SARS-CoV-2 viral coinfections on the health of people living with HIV and their access to healthcare.
Coinfections in people living with HIV present a multifaceted challenge, adding complexity to the healthcare dynamics. The first results chapter investigates a cascade of care for people diagnosed with HIV infection among those who were ever infected with HCV in England. Next, the thesis presents findings from a national clinical audit conducted by the British HIV Association (BHIVA) in 2021. The audit was conducted during the COVID-19 pandemic; thus, the audit not only assessed the routine management of HIV/HCV coinfection, but also the impact of COVID-19 on the way that services were managed locally. The second part of the thesis includes the results of a community survey, conducted during the pandemic, and from the BHIVA COVID-19 Registry. The community survey investigated the prevalence of COVID-19-like symptoms and factors associated with the occurrence of those symptoms among people with HIV, whereas analyses of the BHIVA Registry highlight the prevalence of severity presentation and poor outcomes of COVID-19 in this group, along with the factors associated with each outcome. In addition, this section also describes the possible impact of coinfection with hepatitis B/C and other comorbidities on outcomes.
