Outcomes of COVID-19 Related Hospitalization Among People With HIV in the ISARIC WHO Clinical Characterization Protocol (UK): A Prospective Observational Study
Author(s):
Anna Maria Geretti, Alexander J Stockdale, Sophie H Kelly, Muge Cevik, Simon Collins, Laura Waters, Giovanni Villa, Annemarie Docherty, Ewen M Harrison, Lance Turtle, Peter J M Openshaw, J Kenneth Baillie, Caroline A Sabin, Malcolm G Semple
Summary:
Background
Evidence is conflicting about how human immunodeficiency virus (HIV) modulates coronavirus disease 2019 (COVID-19). We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with COVID-19 at 207 centers across the United Kingdom and whose data were prospectively captured by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) World Health Organization (WHO) Clinical Characterization Protocol (CCP) study.
Methods
We used Kaplan-Meier methods and Cox regression to describe the association between HIV status and day-28 mortality, after separate adjustment for sex, ethnicity, age, hospital acquisition of COVID-19 (definite hospital acquisition excluded), presentation date, 10 individual comorbidities, and disease severity at presentation (as defined by hypoxia or oxygen therapy).
Results
Among 47 592 patients, 122 (0.26%) had confirmed HIV infection, and 112/122 (91.8%) had a record of antiretroviral therapy. At presentation, HIV-positive people were younger (median 56 vs 74 years; P < .001) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive protein levels. The cumulative day-28 mortality was similar in the HIV-positive versus HIV-negative groups (26.7% vs. 32.1%; P = .16), but in those under 60 years of age HIV-positive status was associated with increased mortality (21.3% vs. 9.6%; P < .001 [log-rank test]). Mortality was higher among people with HIV after adjusting for age (adjusted hazard ratio [aHR] 1.47, 95% confidence interval [CI] 1.01–2.14; P = .05), and the association persisted after adjusting for the other variables (aHR 1.69; 95% CI 1.15–2.48; P = .008) and when restricting the analysis to people aged <60 years (aHR 2.87; 95% CI 1.70–4.84; P < .001).
Conclusions
HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19.
Ref:
Anna Maria Geretti, Alexander J Stockdale, Sophie H Kelly, Muge Cevik, Simon Collins, Laura Waters, Giovanni Villa, Annemarie Docherty, Ewen M Harrison, Lance Turtle, Peter J M Openshaw, J Kenneth Baillie, Caroline A Sabin, Malcolm G Semple, Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study, Clinical Infectious Diseases, Volume 73, Issue 7, 1 October 2021, Pages e2095–e2106, https://doi.org/10.1093/cid/ciaa1605
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Published:
October 1, 2021